The game's gameplay has been said to be very similar gameplay of Capcom's Monster Hunter series of video games, however unlike the Monster Hunter series the game possesses a large storyline which can be experienced fully with names and voice actors in single-player mode. Players play as a young, previously unemployed, warrior who has decided to go up against powerful creatures called "Aragami"; warriors who face these beasts are called "God Eaters". The game boasts a mission-based single-player mode consisting of more than 100 000 missions inclusive of co-operative play with up to three teammates over local adhoc wireless multiplayer or AI-controlled teammates. The North American version of the game will also support the PlayStation 3's adhoc Party. The game also features character creation allowing customization of hair style, hair color, face, skin, clothing, voice as well as weapons using special materials. Equipment is divided into three groups: Blade, Gun, and Shield. Weapons can be switched between melee, ranged and shield in-mission.
The story revolves around the 6 main members of an anti-monster organization called Fenrir. The player will lead the veteran members named Rindou, Soma, Sakuya, Kota, and Alisa. While assignments will come from Tsubaki, an instructor.
Rindou's name has been changed to Lindow in the North American release.